Interactions that may increase drug availability essay

N521 Advanced Pharmacology interactions that may increase drug availability essay

Module 2 Discussion 1

Potential interactions, in this case, are likely to arise due to various medications, which are taken by the patient to treat different conditions. A.C is currently taking herbal medicines particular St. John’s Wort to manage her depression, iron pills for anaemia, Xanax for her anxiety, and prednisone to manage asthma exacerbation.

Specifically, multiple drug interactions are likely to arise through St. John’s Wort, which is herbal remedy used as an antidepressant. This type of medication induces cytochrome-p450 enzymes in the body. Various tissues of the body, including the liver, have cytochrome-p450 Interactions that may increase drug availability essay. This type of enzyme is involved in the synthesis and breakdown of hormones. Also, cytochrome-p450 is involved in the metabolism of drugs in the body (Foti & Dalvie, 2016). Therefore, the intake of many types of medications is likely to increase or decrease the level of cytochrome-p450 in the body. Consequently, A.C experience difficulty in the metabolism of these medications. Additionally, St. John’s Wort will inhibit alprazolam that is broken down by cytochrome-p450 in the liver. This action, will, in turn, lead to a significant increase in the level of bioavailability of cytochrome-p450 in the body. An increase in drug availability occurs due to a rise in the usage and overdose of various types of drugs. For instance, the level of opioid prescriptions that were dispensed by U.S. pharmacies tripled from 1991 to 2011 (National Institute of Drug Abuse, 2018). These prescriptions increased from 76 million to 219 million during this period. On the hand, some interactions are likely to decrease drug availability. A decrease in drug availability occurs due to the shortage of drugs in the country. Practitioners observe safety measures due to a decrease in drug availability in the country. They are cautious when prescribing drugs to patients to ensure the available drugs are enough. Health officers should check potential for interactions during co-administration of various medications. Interactions that may increase drug availability essay.


Foti, R. S., & Dalvie, D. K. (2016). Cytochrome P450 and non–cytochrome P450 oxidative metabolism: Contributions to the pharmacokinetics, safety, and efficacy of xenobiotics. Drug Metabolism and Disposition, 44(8), 1229-1245.

National Institute of Drug Abuse. (2018). Prescription Opioids and Heroin: Increased drug availability is associated with increased use and overdose. Retrieved from Interactions that may increase drug availability essay

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